NEWCASTLE, DUKES or. Within the space of a century there were no less than four successive creations of dukes of Newcastle. William Cavendish, nephew of the first earl of Devonshire, was raised to the dignity of duke of Newcastle-upon-Tyne in 1664. His son and successor Henry died leaving daughters only, and one of these married John Holies, earl of Clare, who was created duke in 1694. This duke died also without male issue in 1711, leaving his estates to his sister's son Thomas Pelham, who, with other dignities, had the title of duke of Newcastle-upon-Tyne conferred on him in 1715, and a nephew-in-law, whose descendants (Pelham-Clintons) have of Newcastle, and one duchess, call for separate notice :-